Welcome to Complix

Complix is a biopharmaceutical company focused on the discovery and development of Alphabodies™, a novel class of biopharmaceuticals that offer significant advantages over existing protein based therapies. Alphabodies™ bind with high affinity to a wide range of disease targets and are particularly suited to address certain targets that are difficult to reach with antibodies or other types of protein scaffolds. Due to their unique stability and versatility Alphabodies™ can be delivered via alternative non-injectable routes of administration, unlike most therapeutic proteins.

The Alphabody™ drug development engine is based on the vision that an ideal therapeutic protein should contain a set of key properties that are not present, in a combined way, in monoclonal antibodies or in any other currently available therapeutic proteins. By integrating structural properties of certain naturally occurring human proteins with computer-aided design concepts, the scientific founders of Complix have developed a novel protein scaffold that harbors many of the desired characteristics of an optimal therapeutic molecule: the “Alphabody”.

Complix´s current R&D focus is on the development of Alphabody™ based therapies for autoimmunity and infectious diseases. Complix is conducting its drug development programs in close collaboration with leading international research institutes possessing world-class expertise in these selected therapeutic areas.

Through the filing of several broad patent applications Complix has established a strong intellectual property position on the Alphabody™ platform. Because the Alphabody™ structure is totally unrelated to immunoglobulins, Alphabodies™ are independent of antibody based patent claims.


Structure of an Alphabody™ in ribbon representation

Structure of an Alphabody™ in ribbon representation:

An Alphabody™ comprises 3 associated alpha-helices (in rainbow colors) connected by flexible linker loops (in light blue) forming a single chain protein. Core residues of the central coil are shown as yellow ball-and-sticks.

Latest news

 

Complix' Alphabody™ Protein Therapeutics Demonstrate Activity against both Undruggable Extracellular and Intracellular Disease Targets

IAVI and Belgium-Based Biotech Complix NV Partner on a Novel Approach to HIV Vaccine Design

Complix selects first Alphabody™ development candidate

Complix appoints Dr Thore Hettmann as Head of Therapeutic Development

Complix will be presenting at BioPharm America, September 7-9, 2011 in Boston

Complix extends Series A financing to EUR 7 million with Crédit Agricole Private Equity

Complix receives EUR 1.6 million IWT grant to accelerate development of therapeutic Alphabodies™

Complix presents at BIO-Europe 2010

Complix Luxembourg S.A. receives financial support from the Ministry of Economy and Foreign Trade.