Technology

Beneficial properties of Alphabodies™

Alphabodies™ are single-chain, triple-stranded coiled coil proteins with a molecular weight of between 10 and 14 kDa (10 to 15 times smaller than antibodies). They can bind with high affinity to a wide range of molecular targets and display the following beneficial characteristics as therapeutic drugs:

• Due to their unique structural properties, Alphabodies™ can bind to certain types of targets that are not easily accessible to antibodies or other types of protein scaffolds.
• Despite their small size and simple structure, Alphabodies™ can display more than one antigen binding site on their surface; this means that a single Alphabody™ domain can display multi-specific target binding, a feature hardly achievable with antibodies or other known protein scaffolds.
• Alphabodies™ are extremely stable (melting temperature of > 120 °C), can be autoclaved, can be lyophilized, and are highly resistant to various proteases. These properties allow the development of different formulations and alternative modes of administration (such as topical or pulmonary). Additionally, this means that Alphabody™ based products will exhibit superior shelf-live properties as compared to most protein therapeutics.