The three-dimensional (3-D) structure of an Alphabody™ is characterized by a central coil of 3 associated alpha-helices connected by linker loops, extruding at each end of the coil to form a single chain protein, in an anti-parallel format. This particular 3-D structure provides the Alphabody™ with some of its special features, including its extreme stability and unusual flexibility with respect to target binding.
The potential target space for Alphabodies™ is extremely diverse and comprises a wide variety of molecular structures, including: small peptides, large proteins (such as enzymes or receptors), small chemicals and nucleic acids. Thus, Alphabodies™ hold significant promise for the development of novel therapeutics against multiple disease targets, including those that are difficult to access with antibodies or other currently available protein scaffolds.
The three-dimensional (3-D) structure of an Alphabody™